OPZELURA is a prescription medicine used on the skin (topical) for the treatment of a type of vitiligo called nonsegmental vitiligo in adults and children 12 years of age and older.

Consistency Matters with OPZELURA

Repigmentation is a gradual process that takes time, but nonsegmental vitiligo never takes a day off. If you're pursuing treatment, you'll have to be just as consistent—whether OPZELURA was prescribed for yourself or someone you care for. Apply OPZELURA cream twice each day (as directed by a healthcare provider). With the right tools and support, you could turn a daily treatment regimen into a normal part of your morning and evening routine. Imagine that.

In order to achieve a satisfactory patient response with OPZELURA, some patients may have to continue treatment for more than 6 months. If repigmentation doesn't occur during the first 6 months, talk to your healthcare provider.



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Sam, OPZELURA patient*

*Individual results may vary. OPZELURA is not for everyone.

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Repigmentation: Reimagine what's possible

Wondering what's possible with OPZELURA? Reimagine what repigmentation can look like. The following photos include computer-generated images of study results. They have been created based on the data shown in two clinical trials for OPZELURA. OPZELURA was studied in two clinical trials for 6 months in participants aged 12 and older with nonsegmental vitiligo on up to 10% of their total body surface area (BSA). Phototherapy was not permitted during the trial. These photos represent pigmentation before treatment with OPZELURA, after 3 months of treatment, and at 6 months of treatment. Repigmentation may continue beyond 6 months.

Before treatment

Patient's face before treatment with OPZELURA

Visualization After 3
months of treatment
with opzelura

Visualization after 3 months of treatment with OPZELURA

Visualization at 6
months of treatment
with opzelura

Visualization after 6 months of treatment with OPZELURA

Areas where the hair follicles are sparse, absent or have turned white may not repigment.

Real person with vitiligo; not an OPZELURA patient. Includes computer-generated images of results.

Individual results may vary. Results not typical.

A Gradual Process

The skin's process of repigmentation takes time. Studies of OPZELURA patients have tracked their progress at 6 months, 1 year, and 2 years—and we've seen a trend of improvement at each milestone in the majority of patients. Individual results may vary.

Everyday tools for keeping up with treatment

Use these handy resources to help make applying OPZELURA cream part of your twice-daily routine.


Record thoughts and results in this downloadable journal, which can guide future discussions with your healthcare provider.

Opzelura On Trac
Mobile App

Our treatment tracking app, brought to you by Incyte Corporation, helps you track and get reminders for the treatment plan developed by you and your healthcare provider.

Habit Tracker

Track your progress and stay motivated by checking off each day of completed treatment during the first six months of your treatment journey. Take photos so you can easily track your progress.

Give your healthcare provider the full download

When a healthcare provider prescribes OPZELURA for you or someone you care for, the conversation shouldn't end there. Through ongoing discussions, they can help you keep the treatment plan on track.

  • Share how you have, or haven't, been able to make OPZELURA cream a part of your daily routine.
  • Show any progress you've noticed since your last visit.
  • Tell them how you've been feeling about your treatment experience.
  • Let them know about any other medications you're taking or other treatments you are using for your nonsegmental vitiligo.



  • "Am I applying OPZELURA 
    correctly?" (quantity, surface area, etc.)
  • “Is there anything else I should be doing to protect my skin—for instance, wearing a specific type of sunscreen?”
  • “Should I apply sunscreen or other hygiene products before or after I apply OPZELURA?”
  • “Are there areas to avoid when applying OPZELURA?”


  • “How long should I expect it to take for my skin to repigment?”
  • “Which areas of the body are likely to repigment the fastest?”
  • “What signs of repigmentation should I be looking out for?”
  • “Are there any side effects I should be looking out for?”


We're here to help as you talk with your 
healthcare provider about whether 
OPZELURA may be right for you.

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Indication and Usage

OPZELURA is a prescription medicine used on the skin (topical) for the treatment of a type of vitiligo called nonsegmental vitiligo in adults and children 12 years of age and older.

The use of OPZELURA along with therapeutic biologics, other JAK inhibitors, or strong immunosuppressants such as azathioprine or cyclosporine is not recommended.

It is not known if OPZELURA is safe and effective in children less than 12 years of age with nonsegmental vitiligo.

Important Safety Information

OPZELURA is for use on the skin only. Do not use OPZELURA in your eyes, mouth, or vagina.

OPZELURA may cause serious side effects, including:

Serious Infections: OPZELURA contains ruxolitinib. Ruxolitinib belongs to a class of medicines called Janus kinase (JAK) inhibitors. JAK inhibitors are medicines that affect your immune system. JAK inhibitors can lower the ability of your immune system to fight infections. Some people have had serious infections while taking JAK inhibitors by mouth, including tuberculosis (TB), and infections caused by bacteria, fungi, or viruses that can spread throughout the body. Some people have been hospitalized or died from these infections. Some people have had serious infections of their lungs while taking OPZELURA. Your healthcare provider should watch you closely for signs and symptoms of TB during treatment with OPZELURA.

OPZELURA should not be used in people with an active, serious infection, including localized infections. You should not start using OPZELURA if you have any kind of infection unless your healthcare provider tells you it is okay. You may be at a higher risk of developing shingles (herpes zoster) while using OPZELURA.

Increased risk of death due to any reason (all causes): Increased risk of death has happened in people 50 years of age and older who have at least 1 heart disease (cardiovascular) risk factor and are taking a medicine in the class of medicines called JAK inhibitors by mouth.

Cancer and immune system problems: OPZELURA may increase your risk of certain cancers by changing the way your immune system works. Lymphoma and other cancers have happened in people taking a medicine in the class of medicines called JAK inhibitors by mouth. People taking JAK inhibitors by mouth have a higher risk of certain cancers including lymphoma and lung cancer, especially if they are a current or past smoker. Some people have had skin cancers while using OPZELURA. Your healthcare provider will regularly check your skin during your treatment with OPZELURA. Limit the amount of time you spend in the sunlight. Wear protective clothing when you are in the sun and use a broad-spectrum sunscreen.

Increased risk of major cardiovascular events: Increased risk of major cardiovascular events such as heart attack, stroke, or death have happened in people 50 years of age and older who have at least 1 heart disease (cardiovascular) risk factor and taking a medicine in the class of medicines called JAK inhibitors by mouth, especially in current or past smokers.

Blood clots: Blood clots in the veins of your legs (deep vein thrombosis, DVT) or lungs (pulmonary embolism, PE) can happen in some people taking OPZELURA. This may be life-threatening. Blood clots in the vein of the legs (deep vein thrombosis, DVT) and lungs (pulmonary embolism, PE) have happened more often in people who are 50 years of age and older and with at least 1 heart disease (cardiovascular) risk factor taking a medicine in the class of medicines called JAK inhibitors by mouth.

Low blood cell counts: OPZELURA may cause low platelet counts (thrombocytopenia), low red blood cell counts (anemia), and low white blood cell counts (neutropenia). If needed, your healthcare provider will do a blood test to check your blood cell counts during your treatment with OPZELURA and may stop your treatment if signs or symptoms of low blood cell counts happen.

Cholesterol increases: Cholesterol increase has happened in people when ruxolitinib is taken by mouth. Tell your healthcare provider if you have high cholesterol or triglycerides.

Before starting OPZELURA, tell your healthcare provider if you:

  • have an infection, are being treated for one, or have had an infection that does not go away or keeps coming back
  • have diabetes, chronic lung disease, HIV, or a weak immune system
  • have TB or have been in close contact with someone with TB
  • have had shingles (herpes zoster)
  • have or have had hepatitis B or C
  • live, have lived in, or have traveled to certain parts of the country (such as the Ohio and Mississippi River valleys and the Southwest) where there is an increased chance for getting certain kinds of fungal infections. These infections may happen or become more severe if you use OPZELURA. Ask your healthcare provider if you do not know if you have lived in an area where these infections are common.
  • think you have an infection or have symptoms of an infection such as: fever, sweating, or chills, muscle aches, cough or shortness of breath, blood in your phlegm, weight loss, warm, red, or painful skin or sores on your body, diarrhea or stomach pain, burning when you urinate or urinating more often than usual, feeling very tired.
  • have ever had any type of cancer, or are a current or past smoker
  • have had a heart attack, other heart problems, or a stroke
  • have had blood clots in the veins of your legs or lungs in the past
  • have high cholesterol or triglycerides
  • have or have had low white or red blood cell counts
  • are pregnant or plan to become pregnant. It is not known if OPZELURA will harm your unborn baby. There is a pregnancy exposure registry for individuals who use OPZELURA during pregnancy. The purpose of this registry is to collect information about the health of you and your baby. If you become exposed to OPZELURA during pregnancy, you and your healthcare provider should report exposure to Incyte Corporation at 1-855-463-3463.
  • are breastfeeding or plan to breastfeed. It is not known if OPZELURA passes into your breast milk. Do not breastfeed during treatment with OPZELURA and for about 4 weeks after the last dose.

After starting OPZELURA:

  • Call your healthcare provider right away if you have any symptoms of an infection. OPZELURA can make you more likely to get infections or make worse any infections that you have.
  • Get emergency help right away if you have any symptoms of a heart attack or stroke while using OPZELURA, including:
  • discomfort in the center of your chest that lasts for more than a few minutes, or that goes away and comes back
  • severe tightness, pain, pressure, or heaviness in your chest, throat, neck, or jaw
  • pain or discomfort in your arms, back, neck, jaw, or stomach
  • shortness of breath with or without chest discomfort
  • breaking out in a cold sweat
  • nausea or vomiting
  • feeling lightheaded
  • weakness in one part or on one side of your body
  • slurred speech
  • Tell your healthcare provider right away if you have any signs and symptoms of blood clots during treatment with OPZELURA, including: swelling, pain, or tenderness in one or both legs, sudden, unexplained chest or upper back pain, or shortness of breath or difficulty breathing.
  • Tell your healthcare provider right away if you develop or have worsening of any symptoms of low blood cell counts, such as: unusual bleeding, bruising, tiredness, shortness of breath, or fever.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

The most common side effects of OPZELURA in people treated for nonsegmental vitiligo include: acne at the application site, itching at the application site, common cold (nasopharyngitis), headache, urinary tract infection, redness at the application site, and fever.

These are not all of the possible side effects of OPZELURA. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Incyte Corporation at 1-855-463-3463.

Please see the Full Prescribing Information, including Boxed Warning, and Medication Guide for OPZELURA.